益心舒胶囊治疗冠心病心绞痛100例临床观察

Efficacy of Yixinshu Capsules for Patients with Coronary Artery Disease and Angina Pectoris:Analysis of 100 Cases

目的:观察益心舒胶囊治疗冠心病心绞痛的临床疗效和安全性。方法:将150名患者按2∶1随机分为治疗组100例,对照组50例;治疗组服用益心舒胶囊加硝酸异山梨酯治疗,对照组服用硝酸异山梨酯治疗,疗程均为4周。结果:治疗组的临床总有效率为95%,对照组为80%。治疗组对改善临床胸闷、气短、心悸、出汗、口干、头晕乏力及心绞痛等方面疗效明显好于对照组(P<0.05);两组治疗后均对心电图有一定的改善作用,组间比较无显著性差异(P>0.05);治疗组患者经治疗后心率、收缩压、舒张压均有明显改善(P<0.05或P<0.01),对照组此3项指标无明显改善(P>0.05);治疗组降低收缩压比对照组疗效好(P<0.05)。结论:益心舒胶囊治疗冠心病心绞痛有较好疗效。

OBJECTIVE： To evaluate the efficacy and safety of Yixinshu capsules in the treatment of coronary artery disease and angina pectoris. METHODS： A total of 150 patients were randomized to receive either Yixinshu capsules plus Isosorbide Dinitrate tablets （treatment group, n = 100） or Isosorbide Dinitrate tablets alone （control group, n = 50） for 4 weeks. RESULTS： The total clinic response rate was 95% for the treatment group vs. 80% for the control group. The treatment group showed better curative efficacy than the control group with regard to the improvement of chest distress, short breath, palpitation, diaphoresis, drug mouth, dizziness, fatigue and angina pectoris （ P 〈 0.05）. The electrocardiogram findings improved in both of the two groups and the differences were nonsignificant between the two groups （ P 〉 0.05）. The treatment group showed marked improvement in heart rate, systolic blood pressure and diastolic blood pressure after treatment （ P 〈 0.05 or P 〈 0.01）, but the difference in the control group was nonsignficant after treatment （ P 〉 0.05）. The systolic pressure in the treatment group had a better reduction than in the control group （P 〈 0.05）. CONCLUSION： Yixinshu capsules have proved curative efficacy for coronary artery disease and angina pectoris.