摘要
棉酚(gossypol)是一种天然黄色多酚类化合物,主要存在于棉花的根、茎和种子中。最早作为一种男性节育药为人们所熟知,后又试用于治疗女性激素依赖性疾病,包括子宫内膜异位症、子宫肌瘤、功能失调性子宫出血和痛经等。进一步研究发现,棉酚具有多种生物活性,如抗炎、抗疟、抗病毒及抗氧化等,尤其是具有明显的诱导肿瘤细胞凋亡的能力。
Gossypol is a kind of yellow polyphenolic compounds extracted from root, stem and seed of the cotton plant. It had received significant attention for its potential application as a male antifertility agent. Then it was used to treat female hormone-dependent diseases, for instance, endometriosis, hysteromyoma, uterine bleeding and dysmenorrheal. Current recent researches showed that gossypol has multiple biological activities,such as anti-inflammatory,antimalarial,antiviral, antioxidant activities and so on,especially the activity to induce tumor cell apoptosis.
出处
《基础医学与临床》
CSCD
北大核心
2010年第1期93-96,共4页
Basic and Clinical Medicine
关键词
棉酚
药理作用
抗肿瘤
gossypol
pharmacological action
anti-cancer