结直肠癌个体化治疗的研究进展被引量：1

Progress on individualijed therapy of colorectal cancer

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摘要化疗在晚期大肠癌的治疗中具有重要地位。不同化疗药物的选择影响疗效和预后。以药物基因组学为基础的大肠癌个体化治疗开始得到重视,本文就分子标记对大肠癌化疗药物包括氟脲嘧啶类、奥沙利铂、伊立替康及分子靶向药物疗效影响的研究现状进行综述,探讨大肠癌个体化治疗发展。 Chemotherapy plays an important role in advanced colorectal cancer. Patients may show various clinical response to selection different drugs. The importance of individual therapy based on pharmacogenomics has been emphasized in cancer therapy. To explore the individual therapy of colorectal cancer,the progress of molecular markers which influence the efficacy of anti-tumor drugs containing fluorouracil,oxaliplatin,CPT-11,monoclonal antibody drugs is reviewed in this article.

作者李进何敬东

机构地区南京医科大学附属淮安医院肿瘤内科

出处《基础医学与临床》 CSCD 北大核心 2010年第1期97-99,共3页 Basic and Clinical Medicine

基金江苏省自然科学基金(BK2008192) 江苏省卫生厅资助项目(H200653)

关键词结直肠癌个体化治疗分子标志 colorectal cancer individual therapy molecular markers

分类号 R735.34 [医药卫生—肿瘤]

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