四氢异喹啉类生物碱的生物活性多样性及其作用机制

Bioactivity diversity and functional mechanism of etrahydroisoquinoline alkaloids

四氢异喹啉类生物碱在自然界中分布广泛,有些药物在临床上已广泛应用。随着对四氢异喹啉类生物碱研究的深入,越来越多新的生物活性、新的作用机制和靶点被发现和揭示,此类生物碱生物活性的多样性受到人们广泛关注。本文综述了近五年来四氢异喹啉类化合物在抗肿瘤、抗菌、抗病毒、抗炎、抗凝血、支气管扩张及中枢神经系统作用等方面的活性及机制研究的新进展,旨在为四氢异喹啉类生物碱的活性研究提供思路和启示,为寻找先导化合物、合理设计药物分子提供依据。

Tetrahydroisoquinoline alkaloids distributed widely in the nature and some have a broad application in clinic. More attention has been paid in recent years on this type of alkaloid, owing to the diverse range of biological activities exhibited by these alkaloids and the discovery of new functional mechanisms and molecular targets underlying these activities. This article summarized the recent advances in the biological activities and functional mechanism of tetrahydroisoquinoline, which included the activities such as antitumor, antibiotic, antivirus, anti-inflammatory, anticoagulation, bronchodilation, and the action on central nervous system, with the purpose of providing some ideas in the study of biological activity of this type of alkaloid and in the search for lead-compound and rational drug design.