小花异裂菊中的微量新成分(英文)

Minor new constituents from Heteroplexis micocephala

通过硅胶和PharmadexLH-20凝胶柱色谱以及反相HPLC等多种分离技术的组合应用,从小花异裂菊全草乙醇提取物中分离得到了2个微量新化合物:半日花烷-12,14-二烯-6β,7α,8β,17-四醇(1)和2,3-顺式-6-乙酰基-5-羟基-2-(羟甲基乙烯基)-2,3-二氢苯并呋喃-3-醇当归酸酯(2),以及1个微量新天然产物:6-甲氧基-4-甲基-3,4-二氢-2H-1-萘酮(3)。运用包括二维核磁共振实验的波谱学数据解析确定了它们的结构。

By using a combination of various chromatographic techniques including column chromatography over silica gel and Pharmadex LH-20 and reversed-phase HPLC, two minor new compounds, labda-12, 14-dien- 6β, 7α, 8β, 17-tetraol （1）, 2, 3-cis-6-acetyl-5-hydroxy-2-（hydroxymethylvinyl）-2, 3-dihydrobenzofuran-3-ol angelate （2）, and a minor new natural product 6-methoxy-4-methyl-3, 4-dihydro-2H-naphthalen-1-one （3） have been isolated from an ethanolic extract of Heteroplexis micocephala. Their structures were elucidated with spectroscopic data analysis including 2D NMR experiments.