单晶硅阳极氧化层表面骨状磷灰石的体外诱导沉积

INDUCTION OF BONE-LIKE APATITE ON SINGLE CRYSTAL SILICON WITH ANODIC OXIDATION LAYER SURFACE

在磷酸钠碱性电解质中对单晶硅(100)进行阳极氧化处理,并将阳极氧化处理后的样品在模拟体液(simulated body fluid,SBF)中浸泡以考察其体外诱导骨状磷灰石沉积能力。用扫描电子显微镜观测体外浸泡前后样品的表面形貌,用电子能谱仪和X射线衍射仪研究阳极氧化后与体外浸泡不同时间后样品表面的成分。结果表明:单晶硅在10%的磷酸钠电解质中于5～20mA/cm2阳极氧化后,其表面原位形成火山口状结构,在SBF中浸泡1d后有磷灰石在单晶硅的阳极氧化层表面成核,浸泡6d后诱导形成了纳米骨状缺钙磷灰石层,体现出良好的体外诱导活性,表明阳极氧化处理是一种有希望应用于改善生物学与医学用单晶硅表面生物相容性的有效途径。

Single crystal silicon （100） was subjected to anodization in sodium phosphate alkaline medium,and then the anodic oxidation layer surface on silicon was soaked in a simulated body fluid （SBF） to investigate the in vitro induction for apatite.The morphologies of the specimens with pre-and post-soaking in the SBF were observed by scanning electron microscope.The compositions of the anodized and the SBF-soaked specimens were determined by electron dispersive spectroscopy and X-ray diffractometer.The results show that crater-like morphology in-situ forms on silicon surface after anodization at 5-20 mA/cm 2 in 10% sodium phosphate electrolyte.The nuclei and Ca-deficient bone-like coating with nano-sized apatite were formed on the silicon anodic surface after soaking in the SBF for 1 d and 6 d,respectively,indicating that the anodic surface favored the promotion of the minerization of bone-like apatite on silicon.This anodization approach could be used as a promising and efficient method for improving the surface biocompatibility of bio-inert single crystal silicon applied in the fields of biology and medicine.