神经生长因子与高原眼底病

Nerve growth factor and high altitude eyeground disease

神经生长因子(nerve growth factor,NGF)为神经系统最为重要的神经营养因子之一。在眼科方面,NGF对视网膜神经节细胞的存活及视神经纤维的再生起着极其重要的作用,而高原低氧环境可抑制NGF在视网膜中的表达,影响视网膜修复。本文就NGF及其受体在视网膜的表达、对视网膜的保护作用、高原眼底病以及高原环境下NGF的视网膜表达特征作一综述,并讨论NGF在高原眼底病治疗中的应用前景。

Nerve growth factor（NGF） is one of the most important neurotrophic factors in nervous system.In ophthalmology,NGF plays an important role in the survival of retinal ganglial cells and in the regeneration of nerve fibers,and high altitude hypoxia can inhibit the expression of NGF in retina to influence the recovery of retina.This article reviews the expression of NGF and its receptors in retina and their protective effects on retina,the characteristics of NGF expression under high altitude hypoxia environment and the manifestation of high altitude eyeground diseases.The application of NGF in the treatment of high altitude eyeground diseases is also discussed.