肝缺血再灌注损伤时氧自由基的变化及丹参的防治作用

Change of oxygen free radical and protective effect of Rodix salviae miltiorrhiae during hepatic ischemia-reperfusion

为了探讨肝缺血再灌注时氧自由基对肝脏的影响及丹参的保护作用。本实验通过在肝缺血再灌注损伤大鼠模型上,观察肝组织中丙二醛(MDA)含量和血清丙氮酸转氮酶(ALT)的变化,以及两者变化的相关关系。结果显示,肝缺血再灌注时肝组织中MDA和血清ALT均显著增高,且两者呈正相关;丹参能显著降低肝组织MDA的含量及血清中的ALT。结果表明,氧自由基参与了肝缺血再灌注损伤,丹参对肝缺血再灌注损伤具有保护作用。

To explore the effect of oxygen free radical and the protective effect of Radix Salviae miltiorrhiae (RSM) to hepatic ischemia-reperfusion injury. The model of hepatic ischemia-reperfusion injury was established by occlusion of hepatic artery and portal vein in the rats. The molonal dehyde(MDA) in hepatic tissue and serum ALT were measured. The result shown that MDA in hepatic tissue and serum ALT in crease significantly in the ische-nia - reperfrsion group. But reduse significantly in prevention group. The results suggested that oxygen free radical play a important role in hepatic ischenia - reperfusion injury and RSM could have protective effect to hepatic ischema-reperfusion jnjury.