美罗培南治疗神经外科手术后颅内感染病例分析

Treatment of postoperative intracranial infection of neurosurgery with meropenem(-analysis of 46 cases)

目的:探讨美罗培南在治疗神经外科手术后合并颅内感染的作用。方法:对2家医院2004年1月-2008年10月,84例神经外科手术后颅内感染病例统计,按静脉应用抗生素不同分A、B2组。A组:静脉滴注美罗培南(meropenem)+鞘内注射治疗46例;B组:静脉应用其他抗生素+鞘内注射治疗38例。结果:A组颅内感染治愈43例(93.5%);B组颅内感染治愈17例(44.7%)。A组术后颅内感染治愈率较B组显著提高(P<0.05)。结论:静脉应用美罗培南+鞘内注射治疗可显著提高神经外科术后颅内感染治愈率。

OBJECTIVE To explore the efficiency of meropenem to treat postoperative intracranial infection of neurosurgery. METHODS 84 patients of postoperative intracranial infection of neurosurgery during January of 2004 to October of 2008 in two hospitals were divided into two groups according to the different antibiotics. In group A, 46 patients were treated with in travenous meropenem plus intrathecal injection; In group B, 38 patients were treated with other kinds of antibiotics intrave nously plus intrathecal injection. RESULTS 43 patients were cured in group A （93.5%）, and 17 in group B （44. 7%）. Cure rate was significantly higher in group A compared with that in group B （P〈0.05）. CONCLUSION Treatment of postoperarive intracranial infection of neurosurgery with intravenous Meropenem plus intrathecal injection is superior to other antibiotic therapy.