尼美舒利分散片联合盐酸氟桂利嗪治疗偏头痛55例疗效观察

Effect of Combined Nimesulide Dispersible Tablets and Flunarizine Hydrochloride on Migraine:Report of 55 Cases

目的观察尼美舒利分散片联合盐酸氟桂利嗪治疗偏头痛的疗效。方法选择110例偏头痛患者,将其随机分为治疗组和对照组,各55例。对照组患者每晚睡前口服盐酸氟桂利嗪10mg,另加用安慰剂100mg,2次/d;治疗组患者在给予盐酸氟桂利嗪(方法同上)的同时,加用尼美舒利分散片100mg,2次/d。15d为1个疗程。比较两组患者治疗1个疗程后的疗效、依从性及随访结果。结果治疗后治疗组治愈、显效、有效、无效分别为1例、36例、15例、3例,对照组分别为0例、20例、17例、18例,两组疗效间差异有统计学意义(P<0.01)。治疗组患者治疗满意度评分和尼美舒利口感满意度评分分别为(3.5±0.7)分和(3.4±0.7)分,对照组分别为(2.2±0.6)分和(1.9±0.5)分,两组比较差异有统计学意义(P<0.01)。随访半年,治疗组患者的痊愈率、复发率分别为58.2%(32/55)和30.9%(17/55),对照组分别为32.7%(18/55)和30.9%(17/55),两组痊愈率间差异有统计学意义(P<0.05),而复发率间差异无统计学意义(P>0.05)。结论尼美舒利分散片联合盐酸氟桂利嗪治疗偏头痛疗效显著,且能显著提高治疗满意度和口感满意度。

Objective To investigate the therapeutic efficacy of combined Nimesulide Dispersible Tablets and Flunari- zine Hydrochloride on Migraine. Methods One hundred ten migraine patients were divided randomly into groups therapy and control, 55 in each. Control group were given orally flunarizine hydrochloride, 10 rag, and placebo, 100 mg, 2 times/d, while therapy group given flunarizine hydrochloride, 10 rag, and nimesulide dispersible tablets, 100 mg, twice/d. A treatment course lasted 15 d. The treatment efficacy, compliance and follow -up results were compared between 2 groups after treatment. Results After treatment, 1 patients were cured, marked effect was noted in 36, effect in 15, no effect in 3 in therapy group, and 0, 20, 17, 18, respectively, in control, the difference was significant （P 〈0. 05）. The scores of satisfactions for treat- ment and nimesulide mouthfeel were 3.5 ＋0.7, 3.4 ~0. 7, respectively, in therapy group, and 2. 2 ~0. 6, 1.91 ~0. 54, re- spectively, in control, the difference was significant （P 〈 0. 01 ）. After half year of follow - up, the cure rate and recurrence were 58. 2% （32/55）, 30. 9% （17/55）, respectively, in therapy group, and 32. 7% （18/55）and 30. 9% （17/55）, respectively, in control, the difference in cure rate was significant （P 〈 0. 05 ）, but in recurrence was not （ P 〉 0.05 ）. Conlusion Combined nimesulide dispersible tablets and flunarizine hydrochloride, effecting remarkably on magraine, can improve significantly patients＇ satisfactions of treatment and mouthfeel.