尖锐湿疣合并淋球菌与解脲支原体感染对复发的影响

Effect of Coinfection of Condyloma Acuminatum Complicated by Neisseria Gonorrhoeae and/or Ureaplasma Urealyticum on Recurrence

目的探讨尖锐湿疣(CA)患者合并性传播疾病病原淋球菌(NG)、解脲支原体(UU)感染和复发情况,为临床治疗提供依据。方法对182例CA患者(试验组)和100例无CA的体检者(对照组)进行NG、UU检测,并对尖锐湿疣患者随访半年,统计其单纯感染及合并感染的复发率。结果182例CA患者中,有74例检出NG和(或)UU,检出率为40.7%。100例对照者中,有11例检出NG和(或)UU,检出率为11.0%,两者差异有统计学意义(P<0.05)。CA组NG和UU的检出率分别为9.9%和33.5%,与对照组NG和UU的检出率分别为1.0%和10%间差异有统计学意义(P均<0.01)。18例CA合并NG感染者中,有7例复发(38.9%);61例CA合并UU感染者中,有23例复发(37.7%);84例单纯CA患者有12例复发(14.3%),复发率各组间差异均有统计学意义(P<0.05)。结论尖锐湿疣患者常合并NG、UU感染,且尖锐湿疣患者中合并NG、UU感染者较单纯尖锐湿疣的复发率升高。因此在尖锐湿疣患者的临床诊治过程中,有必要同时进行NG、UU检测和相应治疗。

Objective To explore the coinfection and recurrence of condyloma acuminatum （CA） with neisseria gon- orrhoeae （NG） and/or ureaplasma urealyticum （UU） to provide a basis for clinical treatment. Methods NG, UU were deter- mined in 182 CA patients （test group） and 100 non -CA subjects for medical examinations （control group）. The CA patients were followed up 6 months. The simple infection and recurrence rate were recorded. Results NG and/or UU was/were detected in 74 of 182 CA patients （40.7%） and in 11 of 100 controls （11.0%）, the difference was significant （P 〈0.05）. The de- tection rate of NG, UU were 9.9%, 33.5%, respectively, in CA group, and 1.0%, 10%, respectively, in control, the difference was significant （ P 〈 0. 01 ）. Seven recurred in 18 CA patients with NG （38. 9% ）, 23 recurred in 61 with UU （37.7%）, 12 recurred in84 simple CA patients （14.3%）, the difference was significant （P〈0.05）. Conclusion CA is often associated with NG, UU infection, and those with NG, UU have a high recurrence as compared with simple CA patients. So NG, UU detection and corresponding treatments are necessary in clinical diagnoses and treatment of CA.