外阴黑色病变11例报告

Eleven Cases of Vulvar Blackened Disorder

自１９９７年５月１０日至１９９８年５月１０日，我院门诊在随机诊疗中收集较典型的外阴黑色病变１１例，发病率为０２％（１１／５４００）。１１例病理组织学检查、光镜、电镜结果一致，均为间变Ⅰ～Ⅱ级，归属于外阴上皮内瘤样改变（ＶＩＮ）。同时进行ＰＣＲ法检测乳头瘤病毒（ＨＰＶ）１６、１８型ＤＮＡ，其结果表明，ＨＰＶ１６ＤＮＡ的阳性率占８１８％，ＨＰＶ１８ＤＮＡ阳性率为９１％。上述结果证明，外阴黑色病变的病因是人乳头瘤病毒（ＨＰＶ１６。

Vulvar blackened disorder is a new disease which generates degeneration or color change in epithelium or mucosa.From May in 1997 to May in 1998,eleven typical cases of such disease were collected and the disease incidence was 0.2%.From the results of microscope,electron microscope and pathological histology,they belong to VIN(Ⅰ～Ⅱ).At the same time,We also found that vulvar blackened disorder was affected by human virus 16 or papilloma virus 18 by the means of PCR,positive rate of HPV 16 was about 81.8% and HPV 18 was 9.1%.It proved that the pathogen of vulvar blackened disease was HPV,especially type 16 and type 18.