琥珀胆碱与维库溴铵间相互作用的临床研究

The Interaction between Succinylcholine and Vecuronium

目的和方法：运用加速度仪在２４例病人中观测了琥珀胆碱对随后使用及对作用部分恢复的维库溴铵时效的影响。结果：琥珀胆碱１ｍｇ／ｋｇ的作用完全恢复后给予维库溴铵，后者的ＥＤ５０及ＥＤ９５值分别比对照组（不用琥珀胆碱）减少４６％（Ｐ＜０．０１）和３９％（Ｐ＜０．０１），恢复指数亦轻度延长。当维库溴铵的Ｔ１恢复至２５％时静注琥珀胆碱１ｍｇ／ｋｇ，结果呈现部分逆转维库溴铵阻滞的效应。结论：琥珀胆碱对随后使用的维库溴铵具有增效作用。

Objective:The interactions between succinylcholine and vecuronium were studied under general anesthesia with fentanyl and nitrous oxide. Methods:Twenty four patients were divided randomly into two groups. In one group, succinylcholine was given to facilitate intubation and vecuronium was given following full recovery from succinylholine. In another group, only vecuronium was given. Dose response relationship of vecuronium was determined in both groups. In 21 patients, when T 1 recoverd to 25% of the control value, 1mg/kg of succinylholine was injected. Results: ED 50 and ED 95 of vecuronoium were reduced by 46%( P< 0 01) and 39% ( P< 0 01) respectively following full recovery from succinylcholine compared with the control group. A partial reversal of vecuronium block was observed when succinylcholine was injected at T 1 25% recovery from vecuronium, and T 1 75% recovery from combined block of vecuronium and succinylcholine occured within 8 8 minutes in average.