59例生脉注射液不良反应文献分析

Literature Analysis of 59 Adverse Drug Reaction Reports of Shengmai Injection

目的探讨生脉注射液不良反应发生的一般规律特点,为临床合理用药提供参考。方法对1994～2008年医药学期刊报道有关生脉注射液致不良反应文献进行整理和分析。结果生脉注射液所致不良反应与年龄无关,男性略多于女性,多在用药过程中半小时内发生。不良反应累及多个系统-器官,临床表现复杂多样,主要表现为变态反应,严重者可出现过敏性休克。结论临床医师与药师应了解生脉注射液所致不良反应的规律和特点,加强其应用的监测,以减少不良反应的发生。

Objective To explore the general pattern and characteristics of adverse drug reactions （ADR） induced by Shengmai injection so as to provide references for clinical rational use of drug. Methods ADR of Shengmai Injection in 59 case, reported in domestic medical journals from 1994-2008, were collected and analyzed. Results the ADR of Shengmai injection were independent of patient＇s age and denpendent of patient＇s sex, male patient were more than female patient. The onset of ADR was usually within 30min after injection. ADR could involve in multiple organs and systems, and clinical manifestations were various, mainly were allergic reaction. Severe allergic reaction could result in anaphylactic shock. Conclusion Doctors and pharmacists should know the pattern and characteristics of ADR, and the use of Shengmai injection should be under strict monitoring to reduce the occurrence of serious ADR.