对胶质疤痕所致神经再生障碍的治疗进展

Recent advances in treatment of glial scar-induced inhibition of nerve regeneration

中枢神经系统损伤形成的胶质疤痕是导致神经再生阻滞的主要障碍。如何促进损伤后神经再生和损伤区域神经网络的重建,以及脑功能恢复,是神经科学领域迫切需要解决的课题。文中主要从抑制外源性胶质疤痕成分和促进内源性再生两方面,对目前胶质疤痕所致神经再生阻滞的治疗进展作一介绍。

Glial scar formed by central nervous system（CNS） injury is the main inhibitory barrier of nerve regeneration.How to promote axonal regeneration after injury,how to accelerate neural network reconstruction and how to improve brain function recovery have become a hot problem to be solved in the field of neuroscience.This article focuses on the recent advances of therapeutic strategies for axonal regeneration.