鞘氨醇代谢物——肿瘤治疗的新靶点

Metabolites of sphingolipids as targets for cancer therapy

神经鞘脂类是细胞膜的结构成分之一。其代谢产物如神经酰胺、鞘氨醇、1-磷酸鞘氨醇亦是具有生物活性的信号分子,可作为第一和(或)第二信使调控着细胞的生命活动,如细胞的增殖、存活、迁移、新生血管形成。鞘氨醇激酶1是调节神经酰胺、1-磷酸鞘氨醇平衡的限速酶。近年研究表明,神经酰胺、鞘氨醇激酶1、1-磷酸鞘氨醇可调控肿瘤细胞代谢的多个环节,由此提示神经鞘脂类代谢产物可作为肿瘤治疗的新靶点。

Sphingolipids are structural components of cellular membranes.Their metabolites,such as ceramide,sphingosine,and sphingosine 1-phosphate are important bioactive molecules,which act as the first or second messengers regulating various cellular activities,including proliferation,survival,migration and neovascularization in vitro and in vivo tumor models.Sphingosine kinases 1（SPK1） is a critical regulator of the balance between ceramide and S1P.Recent studies show that ceramide,SPK1 and S1P can regulate many of the hallmarks of cancer. These studies suggest that these metabolites can serve as novel targets for cancer therapy.