丙型肝炎病毒蛋白作用于细胞信号转导途径的研究进展

Progress in Research of the Role of Hepatitis C Virus Protein in Cell Signal Transduction Pathway

细胞信号转导异常往往与人类疾病的发生、发展密切相关。一些病毒致病和感染机制即为病毒抗原蛋白作用宿主细胞信号转导途径,导致宿主细胞内信号转导发生紊乱。丙型肝炎病毒(HCV)是引发慢性丙型肝炎,导致肝硬化和肝细胞癌发生的主要病原体,但目前HCV的致病机制与宿主内持续感染机制尚不清楚。HCV致病机制可能与HCV表达的蛋白质干扰宿主细胞信号转导途径而导致异常的细胞信号转导有关。研究HCV蛋白对宿主细胞信号转导途径的影响不仅有助于阐明其致病机制,还能为新药设计和寻找新的治疗方法提供新思路和新靶点。本文主要综述了近年来国内外有关HCV蛋白作用细胞信号转导途径的研究进展。

Abnormal cell signal transduction is associated with the occurrence and development of human diseases.Some virus pathogenicity and infection mechanism are due to virus antigen protein acting on the host cell signal transduction pathway,leading to host cell signal transduction disorder.Hepatitis C virus （HCV） is a major pathogen of chronic hepatitis C,which causes cirrhosis and hepatocellular carcinoma.But the pathogenesis of HCV and persistent infection mechanism remain far from clear.HCV pathogenesis may be related to the HCV protein expression interfering host cell signal transduction pathways.The studies of hepatitis C virus proteins acting on host cell signal transduction pathways,not only help to clarify the impact of its pathogenic mechanisms,but also benefit to new drug design and development for new treatment methods.This article summarizes the recent progress in research on the effect of hepatitis C virus protein in cell signal transduction pathways in the past few years.