pI3K、p-Akt和PTEN在鼻咽癌中的表达及意义

Expression of PI3K,p-Akt and PTEN in nasopharyngeal carcinoma and their significance

目的观察鼻咽癌(NPC)组织中pI3K、p-Akt和PTEN表达,探讨它们在鼻咽癌发生中的作用。方法应用免疫组化方法检测60例NPC组织和23例鼻咽部慢性炎症组织中pI3K、p-Akt和PTEN的表达。结果NPC与慢性炎症组pI3K的表达率分别为86.7%(52/60)和60.9%(14/23)(P<0.05);p-Akt表达率分别为76.7%(46/60)和47.8%(11/23)(P<0.05);PTEN的表达率分别为41.7%(25/60)和65.2%(15/23)(P<0.01)。pI3K/p-Akt表达率NPC组明显高于慢性炎症组;PTEN表达率NPC组明显低于慢性炎症组,二组表达均与PTEN表达呈负相关。结论pI3K/Akt信号通路的激活、PTEN的抑制,可能在鼻咽癌的发生中起重要作用。

Objective To investigate the expression of PI3K, pAkt and FIEN, and to evaluate their effects on the tumorigenesis in nasopharyngeal carcinoma. Methods hnmtmohistochemical methods were adopted to examine the expression of PI3K, Akt and PTEN in 60 cases of nasopharyngeal carcinomas and 23 non-tumor nasopharyngeal tissue. Results In NPC and non-tumor cases, positive rates of PI3K were 86.7% （52/60） and 60.9% （14/23） （ P 〈 0.05）, that of p-Akt were 76.7% （46/60） and 47.8% （11/23） （ P 〈 0.05）, and that of PTEN 41.7% （25/60） and 65.2% （15/23） （ P 〈 0.01 ）, respectively. Expression rates of PI3K/p-Akt in the NPC were significantly higher than the non-tumor, and that of PTEN in the NPC were significantly lower than the non-tumor. Conclusion The activation of PI3K/Akt pathway and the inhibition of PTEN expression may play important roles in the tumorigenesis and progression of nasophazyngeal carcinoma.