硝酸酯类药物耐受加重心肌缺血-再灌注损伤——过氧亚硝酸阴离子机制
摘要
硝酸酯类药物是治疗冠心病、高血压及心力衰竭的主要药物。连续使用硝酸酯类药物后（一般为24～48h），出现机体对其敏感性降低的现象称为耐受。临床表现为抗心绞痛效果、血流动力学效应及抗血小板聚集效应明显降低，或加大硝酸酯类药物剂量才可维持其疗效。
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2009年第6期424-426,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
参考文献45
-
1Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev,2007 ,87 :315 -424.
-
2Torreilles J, Gueurin MC. Production of peroxynitrite by zymosan stimulation of mytilus galloprovinciafis haemocytes in vitro. Fish Shellfish Immunol, 1999,9:509 - 518.
-
3Murphy MP, Packer MA, Scarlett JL, et al. Peroxynitrite: a biologically significant oxidant. Gen Pharmac, 1998,31 : 179 - 186.
-
4Beckman JS, Chen J, Ischiropoulos H, et al. Oxidative chemistry of peroxynitrite. Meth Enzymol, 1994,233:229 - 240.
-
5Shigerlaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci, 1994,91 : 10771 - 10778.
-
6Baggiolini M, Wymann MP. Turning on the respiratory burst. Trends Biochem. Science, 1990,15:69 - 72.
-
7Lesnefsky EJ, Moghaddas S, Tandler B, et al. Mitochondrial dysfunction in cardiac disease: ischemira-referfusion, aging, and heart failure. J Mol Cell Cardtiol,2001,33 :1065 -1089.
-
8Estevez AG, Spear N, Manuel SM, et al. Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. Neurosci, 1998,18:923 - 931.
-
9Jourdheuil D, Jonrdheuil FL, Kutchukian PS, et al. Reaction of superoxide and nitrieoxide with peroxynitrite: implications for peroxynitrite mediated oxidation reactions in vivo. Biol Chem, 2001,276: 28799 - 28805.
-
10Lizasoain I, Moro MA, Knowles RG, et al. Nitric oxide and peroxynitcite exert distinct effects on mitochondrial repiration which are differentially blocked by glutathione glucose. Biochem J,1996,314: 877 - 880.
二级参考文献7
-
1Munzel T,Sayegh H,Freeman BA,et al.Evidence for enhanced vascular superoxide anion production in nitrate tolerance.A novel mechanism underlying tolerance and cross-tolerance.J Clin Invest,1995,95:187-194.
-
2Morris SD,Cumming DV,Latchman DS,et al.Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes.A new pharmacological route to stress protein expression? J Clin Invest,1996,97:706-712.
-
3Gori T,Parker JD.Nitrate tolerance:a unifying hypothesis.Circulation,2002,106:2510-2513.
-
4Mihm MJ,Coyle CM,Jing L,et al.Vascular peroxynitrite formation during organic nitrate tolerance.J Pharmacol Exp Ther,1999,291:194-198.
-
5Fan Q,Gao F,Zhang L,et al.Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.Apoptosis,2005,10:1235-1242.
-
6Daiber A,Mulsch A,Hink U,et al.The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine.Am J Cardiol,2005,96(7B):25i-36i.
-
7Ferdinandy P,Schulz R.Nitric oxide,superoxide,and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning.Br J Pharmacol,2003,138:532-543.
-
1刘文力.核苷(酸)类似物初始联合治疗失代偿期乙型肝炎肝硬化的效果及安全性研究[J].河南医学研究,2016,25(11):2062-2063. 被引量：2
-
2曹韵贞.开始抗逆转录病毒治疗的指征和时机[J].世界感染杂志,2005,5(2):93-95.
-
3周家杰,曾伟凤.86例复治涂阳肺结核患者的耐药分析[J].热带医学杂志,2012,12(12):1485-1487. 被引量：7
-
4李宇琛,张华瑞,陈营清.小剂量氯吡格雷治疗高龄老年不稳定型心绞痛疗效观察[J].天津医药,2010,38(1):71-72. 被引量：9
-
5郭继鸿.J波综合征:缺血性J波[J].临床心电学杂志,2014,23(5):328-331. 被引量：20
-
6刘晓东,谢林,钟冰,徐群,栾立标,刘国卿.地尔硫■在8名男子血浆中浓度与PR间隔关系[J].中国药理学报,1996,17(5):411-414.
-
7单联斌,王超,孙玉.盐酸艾司洛尔的血流动力学效应[J].临床医学,2011,31(12):108-108.
-
8马文,龙启忠.呼吸机相关性肺炎常见致病菌及其耐药性分析[J].贵阳医学院学报,2009,34(2):164-166. 被引量：19
-
9梁丽霞,吴贻全,张喜中.比索洛尔与美托洛尔治疗无症状心功能不全高血压的疗效比较[J].现代诊断与治疗,2014,25(5):1022-1024. 被引量：1
-
10徐国光,范存忠.多巴酚丁胺治疗慢性肺心病心力衰竭的血流动力学效应[J].南通医学院学报,1992,12(2):125-126.
