摘要
AIM： To evaluate whether adding azithromycin to firstline Helicobacter pylori （H pylorl） eradication improved eradication and reduced side effects. METHODS： Eligible articles were identified by searches of electronic databases. We included all randomized trials that compared azithromycin-containing with standard triple-therapy regimens for first-line treatment of H pylori infection. Statistical analysis was performed with Review Manager 5.0.10. Sub-analyses were also performed. RESULTS： We identified 14 randomized trials （1431 patients）. Pooled Hpylori eradication rates were 72.01% （95% CI： 58.09%-85.93%） and 69.78% （95% CI： 66.47%-73.09%） for patients with or without azithromycin by intention-to-treat analysis, and the odds ratio （OR） was 1.17 （95% CI： 0.64-2.14）. The occurrence of side effects differed significantly and was 15.81% （95% CI： 12.50%-19.12%） and 25.20% （95% CI： 21.44%-28.96%） for treatment with or without azithromycin, respectively, and the summary OR was 0.58 （95% CI： 0.41-0.82）. Furthermore, the azithromycin-containing group had a lower occurrence of diarrhea, nausea and taste disturbance. CONCLUSION： Our review suggests that azithromycincontaining triple-therapy regimens could be equally effective in eradication of Hpylori compared with standard first-line triple-therapy regimens.
AIM:To evaluate whether adding azithromycin to firstline Helicobacter pylori(H pylori)eradication improved eradication and reduced side effects.METHODS:Eligible articles were identified by searches of electronic databases.We included all randomized trials that compared azithromycin-containing with standard triple-therapy regimens for first-line treatment of H pylori infection.Statistical analysis was performed with Review Manager 5.0.10.Sub-analyses were also performed.RESULTS:We identified 14 randomized trials(1431 patients).Pooled H pylori eradication rates were 72.01%(95%CI:58.09%-85.93%)and 69.78%(95% CI:66.47%-73.09%)for patients with or without azithromycin by intention-to-treat analysis,and the odds ratio(OR)was 1.17(95%CI:0.64-2.14).The occurrence of side effects differed significantly and was 15.81%(95%CI:12.50%-19.12%)and 25.20%(95%CI:21.44%-28.96%)for treatment with or without azithromycin,respectively,and the summary OR was 0.58(95%CI:0.41-0.82).Furthermore,the azithromycin-containing group had a lower occurrence of diarrhea,nausea and taste disturbance.CONCLUSION:Our review suggests that azithromycincontaining triple-therapy regimens could be equally effective in eradication of H pylori compared with standard first-line triple-therapy regimens.
