移植肝抗体介导排斥反应的研究进展

Advances in research on antibody-mediated rejection after liver transplantation

T细胞介导的免疫称为细胞免疫,而由抗体介导的免疫则称为体液免疫,与细胞免疫一样,抗体亦介导了同种/异种移植器官排斥反应.目前,肝移植已成为临床上常做的器官移植手术,新近研究发现移植肝同样存在着抗体介导的排斥反应机制.本文就近年来关于移植肝抗体介导排斥反应的基本理论、机制、病理诊断及治疗等研究进展进行综述.

T cell- and antibody-mediated immunity are also called cellular and humoral immunity, respectively. Both cellular and humoral immunity are known to mediate the rejection after allogeneic/xenogeneic organ transplantation. Liver transplantation is the most common type of organ transplantation. At present, many studies have shown that antibody-mediated immunity plays an important role in the de- velopment of rejection after liver transplanta- tion. In this article, we will review the recent advances in understanding the basic theory, mechanism, pathological diagnosis and treatment of antibody-mediated rejection after liver transplantation.