预处理防治肝缺血再灌注损伤的研究进展

Preconditioning against hepatic ischemia-reperfusion injury: recent advances

肝脏缺血再灌注损伤(ischemia-reperfusion injury,I/R)是困扰肝脏外科发展的一大重症,如何防治I/R一直是研究的热点.预处理通过诱导细胞的内源性保护机制,对肝脏I/R有明显的防治作用,本文就各种预处理对抗肝脏I/R的作用机制作一综述,探讨各种预处理方法的临床应用价值.

Hepatic ischemia-reperfusion injury （I/R） is a major clinical problem that impedes the development of liver surgery. Recently, intensive research has improved our understanding of the mechanisms involved in I/R liver injury. Here, we will briefly review the most promising preconditioning approaches against I/R injury and discuss the mechanisms involved in their therapeutic effects.