摘要
1993年Leeetal在秀丽新小杆线虫中发现编码形成可抑制LIN-14蛋白合成,大小为22nt的小分子RNA基因lin-4,当时并未引起注意.直到2000年,Reinhartetal又在此线虫中发现第二种类似的基因let-7,此后不到一年间又相继发现了数百种类似的小分子RNA,被称为micro-RNAs(miRNAs).近年来,miRNAs的研究突飞猛进.miRNAs与肿瘤发生发展的关系及其潜在的诊断价值是目前研究的热点之一,且在非肿瘤疾病中,miRNAs的研究方兴未艾.现将与肝纤维化发生有关的miRNAs研究作一简介.
In 1993, Lee et al found that 22-nt small-molecule RNAs encoded by the lin-4 gene inhibited the synthesis of LIN-14 protein in Caenorhabditis elegans, which, however, did not attract wide attention. Until 2000, Reinhart et al reported a similar finding in the let-7 gene. In less than a year later, hundreds of types of similar small- molecule RNA-like RNAs, called microRNAs （miRNAs）, were discovered. In recent years, the number of studies on miRNAs is growing by leaps and bounds. The relationship of miRNAs with tumor development and progression and its potential diagnostic value have become a hot research topic. In non-cancer diseases, the research on miRNAs is attracting more attention. Here, we will review the role of micro-RNAs in the pathogenesis of liver fibrosis.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第36期3671-3674,共4页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30570824~~
