转录辅抑制因子CtBP1与其靶基因E-cadherin在结肠腺癌中的表达

Expression of transcriptional corepressor CtBP1 and its target gene E-cadherin in colon adenocarcinoma

目的:探讨转录辅抑制因子CtBP1在结肠腺癌中的表达状况及对其靶基因E-cadherin表达的影响.方法:采用免疫组织化学染色方法检测结肠癌及癌旁组织中CtBP1及E-cadherin的表达.结果:CtBP1在结肠癌组织及癌旁组织中表达阳性率分别为96.25%(77/80)和100%(80/80);E-cadherin在结肠癌组织及癌旁组织中表达率分别为32.50%(26/80)和100%(80/80),且与肿瘤浸润深度相关;CtBP1在结肠癌中表达与E-cadherin不相关.结论:CtBP1对其靶基因E-cadherin表达的抑制并不是由CtBP1的异常表达介导的.

AIM： To investigate the expression of transcriptional corepressor C-terminal-binding protein I （CtBP1） and its target gene E-cadherin in colon adenocarcinoma. METHODS： The expression of CtBP1 and E-cad- herin proteins in colon adenocarcinoma and paired non-neoplastic tissue was assessed by imrnunohistochemistry. RESULTS： The positive rates of CtBP1 expression in colon adenocarcinoma and paired nonneoplastic tissue were 96.25% （77/80） and 100% （80/80）, respectively. The positive rates of E-cadherin expression in colon adenocarcinoma and paired non-neoplastic tissue were 32.50% （26/80） and 100% （80/80）, respectively. The expression of E-cadherin was associated with tumor invasion depth in colon adenocarcinoma. The expression of CtBP1 was not associated with E-cadherin expression in colon adenocarcinoma. CONCLUSION： The transcriptional repression function of CtBP1 does not mediate the dysregulated expression of E-cadherin in colon adeno-carcinoma.