口服硝酸甘油片治疗冠心病临床疗效分析

THE CLINICAL ANALYSIS OF NITROGLYCERINPILLS ON CORONARY HEART DISEASE

用口服硝酸甘油方法治疗８２例冠心病，经临床观察，结果：４６例用消心痛３０ｍｇ／ｄ及３６例用５—单硝酸异山梨酯２０～６０ｍｇ／ｄ治疗，心绞痛缓介率分别为７８．５７％、８１．８２％。对缺血性ＳＴ—Ｔ改善者分别为７８．２６％、８０．５６％，两组疗效无显著差异，Ｐ＞０．０５。治疗两周后，两组药物均产生耐药性，改用口服硝酸甘油片３～６ｍｇ／ｄ经临床观察三周，心绞痛缓介有效率为９８％；缺血性ＳＴ—Ｔ改善者有效率为９７．５６％；心功能改善者７２．７３％。经统计学处理：用口服硝酸甘油比应用消心痛及５—单硝酸异山梨酯治疗有显著差异。Ｘ２分别为８．２７４、１３．３９４、Ｐ＜０．０１，它观察４～６周，心绞痛及ＳＴ—Ｔ未再出现反复现象。本组资料表明：口服硝酸甘油片对缓介心绞痛，改善心肌供血及纠正心力衰竭等方面的疗效明显的优于二硝酸异山梨醇酯（消心痛）及５—单硝酸异山梨酯（丽珠欣乐）。对该药传统的用药方法。

We have treated 82 cases of coronary heart disease by giving orally taken nitroglycerin in cohich,46 cases were treated by giving carvasin 30mg/d and the other 36 cases,by 5-isosorbidde mononitrate 20～60mg/d. The clinical observation indicates that the relieving rates of angina pectoris are respectively 78.57% and 8182%.The improving rates as regards to blood-shortage ST-T are respectively 78.26% and 80.56%,P>0.05.The two groups didn’t show apparently difference in curative effects.Two weeks after treatment drugresistance of both groups developed.Sonitroglycerin pills 3～6mg/d cases given.Afrer another 3 weeks observation,the effective relievin-g rate of angina pectoris was 98%,the effective rate of the improved cases of bloodshortage STT was 97.56% and of cardiofunction 72.73%.Statically the application of orally-taken nitrolycerin is noticeably different from that of carvasin and Sisoiorbide mononitrate.X2 are respectively 8.272 and 13.394,P<0.01.In the following 4～6 weeks,no relapse of anfina pectoris and ST-T cuas observed.It is thus indicated that,in relieving angina pectoris,improving heart muscles blood supply and rectifing heart failure,nitroglycerin pills are remarkably superior to carvasin and S-isosorbide momomitrate.Further research is respected for the traditional application of this medicine.