纳洛酮治疗肝性脑病的疗效观察及机制研究

Investigation on therapeutic effect and mechanism of Naloxone on cirrhotic patients with hepatic encephalopathy

目的研究纳洛酮治疗肝硬化合并肝性脑病的疗效及机制,评价其有效性和安全性。方法肝硬化合并肝性脑病62例,随机分成2组,治疗组42例,对照组20例。2组常规治疗相同,治疗组加用纳洛酮治疗,连用72h观察。对2组病例治疗前后血氨水平、意识变化、总有效率进行比较。结果治疗组患者血氨水平、意识障碍程度较对照组有显著改善,治疗组总有效率90.45%,对照组总有效率65.00%,2组比较差异有统计学意义(P<0.05)。结论纳洛酮治疗肝性脑病是有效和安全的。

Objective To study the effects of naloxone on cirrhotic patients with hepatic encephalopathy（HE）,and evaluate its efficacy and safety.Methods 62 cirrhotic patients with HE were randomly divided into two groups. Experimental group has 42 patients,control group has 20 patients.The routine therapies of two groups were an identical regimen.42 patients in the experimental group were treated with naloxone in addition to routine therapies by 72 hours continual observation.Compared the ammonia level , conscious modification and the total effective rate between before treatment and after treatment.Results Anmmonia level and conscious modification of experimental group has significantly improved.The total effective rate of experimental group was 90.45% ,the total effective rate of control group was 65.00% .There was significant difference in the total effective rate between the two groups （P〈0.05）.Conclusion Naloxone is effective and safe in the treatment of HE.