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大孔树脂对脂蛋白的吸附研究 被引量：1

Adsorption of Lipoprotein onto Macroporous Resin
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摘要 对大孔吸附树脂对低密度脂蛋白(LDL)的体外吸附过程进行研究。对3种大孔树脂在相同的实验条件下进行小牛血清的脂蛋白吸附,通过比较3种树脂对LDL的吸附能力,选取出较适宜进行LDL吸附的大孔树脂D113。然后在吸附柱上进行动态吸附,并通过数学模型进行吸附过程的描述。结果表明:模型的描述与实验结果相一致,对吸附过程的设计和实验有一定的参考价值。 In this study,in vitro adsorption process of low density lipoprotein（LDL） onto macroporous resin was investigated.Lipoprotein from calf serum was used as the material to conduct adsorption experiments by 3 kinds of macroporous resins.The optimal resin was screened in terms of adsorption capacity towards LDL.Results indicated that macroporous resin D113 exhibited the highest adsorption capacity.Meanwhile,dynamic adsorption process was also described using a mathematical mode,which could well fit experimental data.Therefore,this model will provide practical reference for further research of LDL adsorption.
作者 丁勇
机构地区 上海海洋大学食品学院
出处 《食品科学》 EI CAS CSCD 北大核心 2010年第1期76-78,共3页 Food Science
基金 上海市教委优青基金项目(科07-23) 上海市海洋大学博士启动基金项目(06337)
关键词 大孔树脂 低密度脂蛋白 高密度脂蛋白 吸附 macroporous resin low density lipoprotein（LDL） high density lipoprotein（HDL） adsorption
分类号 TQ321 [化学工程—合成树脂塑料工业] TQ328 [化学工程—合成树脂塑料工业]
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参考文献8

  • 1张迎庆,干信,谢笔钧.低密度脂蛋白血液净化研究进展[J].药物生物技术,2004,11(2):116-120. 被引量：8
  • 2余喜讯,万昌秀,乐以伦.低密度脂蛋白分离技术[J].航天医学与医学工程,2002,15(2):144-148. 被引量：7
  • 3CORNELIUS R M, ARCHAMBAULT J, BRASH J L. Identification of apolipoprotein A-I as a major adsorbate on biomaterial surfaces after blood or plasma contact[J]. Biomaterials, 2002, 23: 3583-3587.
  • 4BOSCH T. Practical aspects of direct adsorption of lipoproteins from whole blood by DALI LDL-aplaeresis[J]. Transfusion and Apheresis Science, 2004, 31: 83-88.
  • 5THOMPSON G R. LDL apheresis[J]. Atherosclerosis, 2003, 167: 1-13.
  • 6傅国旗,陈新福,袁直,刘斌,沈彬,何炳林.一种新型低密度脂蛋白吸附剂的制备[J].高等学校化学学报,2004,25(6):1183-1185. 被引量：10
  • 7WANG Y, WALLI A K, SCHULZE A, et al. Heparin-mediated extracor- poreal low density lipoprotein precipitation as a possible therapeutic approach in preeclampsia[J]. Transfusion and Apheresis Science, 2006, 35(2): 103-110.
  • 8CHENG Y, WANG S Q, YU Y T, et al. In vitro, in vivo studies of a new arnphiphilic adsorbent for the removal of low-density lipoprotein[J]. Biomaterials, 2003, 24(13): 2189-2194.

二级参考文献68

  • 1[1]Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low-density lipoprotein hypothesis[J]. Atherosclerosis,1998,141(1): 1-15.
  • 2[2]Orekhov AN, Khashiomov KA, Mukhin DN,et al. Low-density lipoprotein apheresis and regression of atherosclerotic plaque in vitro[J]. Artif Organs,1986,10(6): 466-469.
  • 3[3]Cattin L, Petrucco A, Cazzolato G,et al. Low-density lipoprotein-apheresis decreases oxidized low-density lipoprotein and monocyte to endothelial cells[J]. ASAIO,1997,43(3): 209-213.
  • 4[4]Leitinger N, Pirich C, Blazek I,et al. Decreased susceptibility of low-density lipoproteins to in vitro oxidation after dextran-sulfate LDL-apheresis treatment[J]. Atherosclerosis,1996,126(3): 305-312.
  • 5[5]Bosch T. State of the art of lipid apheresis[J]. Artif Organs,1996,20(4): 292-295.
  • 6[6]Matsuda Y, Malchesky PS,Nose Y. Low-density lipoprotein removal methods by membranes and future perspectives[J]. Artif Organs,1996,20(4): 346-354.
  • 7[7]Nose Y, Usami M, Malchesky PS,et al. Clinical thermofiltration: initial application. Artif Organs,1985,9(4): 425-7.
  • 8[8]Kochnike F, von Bayer H, Schwaner I,et al. Comparison of plasma fractionation filters and filtration techniques in the clinical practice of LDL-apharesis[J]. Trans Am Soc Artif Organs 1986,32(1):388-91.
  • 9[9]Brown MS, Goldstein JL. A receptor-mediated pathway for cholsterolhomeostasis[J]. Science,1986,232: 34-47.
  • 10[10]Hobbs HH, Russell DW, Brown MS,et al. The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein[J]. Annu Rev Genet,1990,24:133-170.

共引文献22

同被引文献17

  • 1崔韬,程焱,王深琪,俞耀庭.新型LDL-吸附剂对血脂影响的实验研究[J].中国生物医学工程学报,2005,24(1):50-53. 被引量：3
  • 2Reimann M, Julius U, Haink K, et al. LDL apheresis improves de- ranged cardiovagal modulation in hypercholesterolemic patients [J]. Atherosclerosis, 2010, 213(1): 212-217.
  • 3Moriarty PM. LDL-apheresis therapy: current therapeutic practice and potential future use[J]. Future Med, 2006, 1(3): 299-308.
  • 4Hu Gang, Cui Ya-dong, Jousilahti P, et al. Joint effect of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol on the risk of coronary heart disease[J]. Eur J Cardiovasc Prey Rehabil, 2011.
  • 5Masaru N, Akira R, Takehiro N, et al. Low density lipoprotein/fib- rinogen adsorbent and adsorption apparatus capable of whole blood treatment: US, 20060089587[P]. 2006-04-27.
  • 6Chen Shun-jie, Jiang Geng-ru, Shan Jian-ping, et al. Combination of maintenance hemodialysis with hemoperfusion: a safe and effective model of artificial kidney[J]. Int J Artif Organs, 2011, 34(4): 339-347.
  • 7Malleshappa P, Ranganath R, Chaudhari AP, et al. Effective use of polymyxin B hemoperfusion in septic shock complicated by urosep- sis[J]. Indian J Nephrol, 2011, 21(1): 41-43.
  • 8Masin V, Blaha M, Stransky P, et al. Optimization of therapeutic procedure during LDL-apheresis-verification of the computerized model in clinical practice[J]. Transfus Apher Sci, 2007, 36(1): 39-45.
  • 9Kinlay S. Low-density lipoprotein-dependent and -independent ef- fects of cholesterol-lowering therapies on C-reactive protein: a meta- analysis[J]. J Am Coil Cardiol, 2007, 49(20): 2003-2009.
  • 10Medina-Urrutia A, Juarez-Rojas JG, Martinez-Alvarado R, et al. High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyc- eride concentrations, and its association with insulin and C-reactive protein[J]. Atherosclerosis, 2008, 201(2): 392-397.

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食品科学
2010年 第1期

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