内皮依赖性舒张因子对豚鼠耳蜗微血管自律运动的影响

The effect of endothelium-derived relaxation factor on specific property of vasomotion of cochlea in guinea pig

为探讨内皮依赖性舒张因子（EDRF／NO）对耳蜗微血管自律运动特性的影响。采用微循环数字图像检测和分析方法，根据微动脉管径动态变化的跟踪测量结果，利用“快速富里叶频谱转换（FFT）”，对耳蜗微血管自律运动的频率特性、收缩特性的特征参数，进行了定量分析。结果表明：在正常状态下，耳蜗微动脉存在运动幅度较小的自律运动。实验发现EDRF／NO能显著增加激动脉自律运动的频率及振幅，增强耳蜗微循环的功能，使耳蜗血流量增加。

By using intravital microscopy measurement with image processing system,contineous diameter changes were measured by self-tracking with computer,the present study is to inyestigate specific property of vasomotion in cochlear microvessels and its responsibility to the endothelium-derived relaxation factor (EDRF/NO). The results demonstrated that the vasomotion of cochlear arteriole existed in normal condition in a small pattern. It was found that the vasomotion was significantly enhanced after administration of L-arginine (which is donor of EDRF/NO),and Larginine induces a sequence of changes in cochlear blood flow. There were significant statistic difference before and after the drug administration. The conclusion suggest that EDRF/NO play an important role in the increase of blood now by improvement of vasomotion.