摘要
为了解有自然流产史早期先兆流产妇女外周血浆β内啡肽(βEP)、促性腺激素释放激素(GnRH)、人绒毛膜促性腺激素(hCG)和孕酮(P4)的变化。随机选择孕7~8周的有反复自然流产史的先兆流产妇女20例,于治疗前及后(孕10~12周)测血浆βEP、GnRH、hCG和P4水平(RIA法)。随机选择正常早孕妇女20名,分别于孕7~8和10~12周进行上述4项测定,收集孕10~12周不全流产妇女外周血同样进行以上测定,后两组作为对照。结果:(1)正常早孕妇女孕10~12周血浆βEP、GnRH、hCG和P4水平比孕7~8周时值明显上升(P<0.01)。(2)孕7~8周时,先兆流产妇女血浆βEP值明显高于正常相应孕周水平(P<0.01),GnRH、hCG和P4则明显低于正常早孕组(P<0.01)。经过给予心理支持、中药综合治疗后,先兆流产症状消失,16例足月分娩,其孕10~12周时的4项水平与相应孕周间无显著差异(P>0.05)。(3)不全流产组除血βEP值明显高于正常早孕组水平(P<0.01)外,其他则明显低于正常妊娠早孕组水平(P<0.01)。认为βEP在自然流产的发生中可能起着重要作用。
Objective: To observe plasma βendorphin (βEP) and gonadotrophin releasing hormone (GnRH), human chorionic gonadotrophin (hCG), progesterone (P4) levels in women of early threatened abortion and with a history of recurrent spontaneous abortions (RSA).Methods: Twenty patients of threatened abortion in 7~8 weeks of gestation were recruited, all of them had a history of 3 or more recurrent unexplained abortions. They were treated with psychological consultation accompanied by traditional Chinese herbs. Blood samples were taken to measure βEP,GnRH, hCG and P4 levels by RIA. The treatments were continued till 10~12 weeks, blood were taken again to compare the changes of these peptides/hormones. Twenty normal pregnant women in 7~8 and 10~12 weeks and 20 incomplete abortion patients in 10~12 weeks composed of two control groups.Results: (1)In normal pregnant women,plasma βEP,GnRH,hCG and P4 levels of 10~12 weeks were significantly higher than that in 7 ̄8 weeks (P<0.01). (2) In threatened abortive patients with RSA, plasma βEP levels of 7 ̄8 weeks were significantly higher than that in normal pregnant women (P<0.01),on the contrary, plasma GnRH,hCG and P4 levels in these patients were significantly lower than that in normal cases (P<0.01). After treatment, 16 of the 20 patients succeeded in maintaining their pregnancies, the levels of four plasma contents during 10~12 weeks were similar to those in normal cases (P>0.05). (3) Plasma βEP levels in patients with incomplete abortions of 10 ̄12 weeks were dramatically higher and GnRH,hCG and P4 lower than that in normal cases (P<0.01)Conclusion: βEP might play an important role in the pathophysiology of spontaneous abortion.
出处
《生殖医学杂志》
CAS
1998年第3期141-144,共4页
Journal of Reproductive Medicine
关键词
先兆流产
Β-内啡肽
早期
Threatened abortion βendorphin Gonadotrophin releasing hormone Human chorionic gonadotrophin Progesterone