摘要
呼出气检测作为一种潜在的新型临床检测手段受到广泛关注。本文详细综述了人体呼出气中挥发性有机化合物(VOCs)的各类检测方法和技术,分别对色谱法、质谱法和光谱及传感器法的原理、特点和最新研究进展进行了介绍,对照总结了目前已确定的异戊二烯、丙酮等疾病生物标志物的各种分析方法和实测数据,并展望了未来的研究动向。
Over hundreds of volatile organic compounds（VOCs）have been detected in human exhaled breath.Some of the organic constituents in exhaled breath can indicate a disease state of the individual or a recent exposure to an environmental pollutant.Determination of VOCs in human breath samples shows great potential in clinical diagnosis as a noninvasive method to replace or complement measurements from blood samples.This review focuses on the recent development of various methods for detection of VOCs in human exhaled breath.The advantages and limitations of the dominant methods including gas chromatography,mass spectrometry,spectroscopy and sensor are all highlighted.The analytical methods and concentration data of several important disease biomarkers such as isoprene and acetone are summarized.The future development trends in this field are also briefly discussed.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2010年第1期140-147,共8页
Progress in Chemistry
基金
国家自然科学基金项目(No.20637020)资助
