摘要
引导组织再生膜(guided tissue regeneration membrane,GTRM)由于能使组织修复再生能力得到最大程度的发挥而广泛应用于各种软硬组织的修复与再生研究及临床医学中。GTRM分为不可吸收与可吸收GTRM,与不可吸收GTRM相比,由于可吸收GTRM越来越多的优点被发现而备受关注。本文阐述了几种常见的可吸收GTRM材料(以胶原为代表的天然生物材料,以聚酯为代表的合成高分子材料和以羟基磷灰石为代表的可降解无机物材料)及其可吸收GTRM在骨缺损、创伤敷料以及防黏连等领域中的主要应用进展,重点综述了可吸收GTRM的主要制备方法---静电纺丝、溶剂浇铸、相转化及其优缺点。
Guided tissue regeneration membrane（GTRM）is widely applied in repair and regeneration of various hard and soft tissues because of improving the tissue regenaretion ability.GTRM is mainly divided into two kinds：non-absorbable and absorbable GTRM.Compared with non-absorbable GTRM,absorbable GTRM is more widely researched and applied for the more and more merits.In this article,the common materials of absorbable GTRM,i.e.natural biomaterials represented by collagen,synthetic polymeric materials represented by polyester and inorganic materials represented by hydroxyapatite are reviewed.And the applications of absorbable GTRM in bone defects,wound dressing,anti-adhesion areas and so forth are also described.The main methods in preparing absorbable GTRM including electrospinning,solvent-casting and phase inversion and the advantages and disadvantages are described emphatically.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2010年第1期179-185,共7页
Progress in Chemistry
基金
国家自然科学基金项目(No.30800230)
上海市科技发展基金重点纳米专项(No.0852nm03600)资助
关键词
可吸收生物膜
引导组织再生
静电纺丝
溶剂浇铸
相转化
absorbable biomembranes
guided tissue regeneration
electrospinning
solvent-casting
phase inversion
