盐敏感性高血压患者的肾脏排泄钠、钾特征的研究

The study of the characterstcs of renal sodium and potassium excretion in salt-sensittive essential hypertensions

为了探讨原发性高血压病病因并对其治疗及预防提供依据,本研究对55例原发性高血压病患者进行了区分盐敏感者的研究及三种状态下肾脏排泄钠、钾和血浆有关激素水平的实验室测查及统计分析,结果表明:盐敏感者为34例,中间型11例,10例盐耐受者.在盐负荷状态下,盐敏感者中大部分(71%)呈现肾排钠增强,且排钠量与收缩压的升高呈正相关(r=0.700,P<0.05);另一部分(29%)的盐敏感者排钠减低,但血压增高幅度大.盐负荷期肾排钾量盐敏感组高于耐受组.盐负荷期与基础状态时相比较,盐敏感组的血浆肾素活性、血管紧张素Ⅱ及醛固酮水平没有得到有效的抑制.提示:盐敏感性高血压患者存在着肾排钾、钠障碍及肾素-血管紧张素-醛固酮系统调节紊乱.

55 essential hypertensives (EHT)had been studied and examinated in identifying saltsen-sitive individuals and laboratory examinations of the renal sodium,potassium excretion,pasmarenin cativity(PRA) ,plasma angiorensin Ⅱ (AngⅡ),plasma aldsterone(ALD)under three states, Atter statistical analysis,So that we can studg the pathogeny and treatmrnt and prevention of EHT. the ersult result showed: The 34 of 55 EHT are classified as salt-sensitivies (71%)hadhigher renal sodium excretion,and latter were correllated with systolic pressure(SBP) (r = 0. 700,P<0. 05), other salt sensitivies (29%) with decreased renal sodium excretion were higher SBP. During salt-loading, the salt-sensitivies had higher renal potassium excretion than that of salt-resistantives. Comparison with basestate,in salt loading the plasma PRA,Ang Ⅱ ,and ALD were not suppressed. This suggccts that salt-sensitives have ahnormalities in renal sodium snd potassium excretion function aid regulalatig disorder in RSSA.