胃癌组织中GST-π表达及其意义

STUDY ON CHANGES OF SERUM SOLUBLE INTERLEUKIN 6 RECEPTOR AND SOLUBLE gp130 IN PATIENTS WITH HEPA TITIS CIRRHOSIS

为了解胃癌组织中谷胱甘肽Ｓ－转移酶－π（ＧＳＴ－π）表达的临床意义，运用流式细胞技术，对７５例胃癌组织及癌旁粘膜组织中ＧＳＴ－π的表达进行了检测；同时用免疫组化法检测胃癌组织中Ｃ－ｅｒｂＢ－２蛋白和ｎｍ２３蛋白。结果：不同病理类型胃癌组织中ＧＳＴ－π的表达无差异（Ｐ＞０．０５）。７５例胃癌组织中ＧＳＴ－π表达水平与癌旁粘膜组织中ＧＳＴ－π水平有统计学差异（ｔ＝１７．４４Ｐ＜０．０１），而ＧＳＴ－π的含量不受Ｃ－ｅｒｂＢ－２蛋白及ＣＥＡ含量的影响（Ｐ＞０．０５）。结论：胃癌组织中ＧＳＴ－π的表达增强，与胃癌细胞生理适应特性有关。

In order to investigate changes of serum soluble interleukin 6 receptor(sIL 6R) and soluble gp130(sgp130)in patients with hepatitis cirrhosis(HC) and its clinical significance,the concentrations of serum sIL 6R and sgp130 were determined by using enzyme linked immunosorbent assay in 34 cases patients with HC.The results showed ① The serum sIL 6R and sgp130 le vels in patients with HC were higher than normal controls( P < 0.01 ).Patients with active HC had a higher sIL 6R and sgp130 levels than those with silence HC( P <0.01).The ratio of serum sIL 6R and sgp130 was decreased in HC and was lower in active HC than in silence HC.②Serum sIL 6R levels had positive correlation with serum gp130 levels( r =0.417, P <0.05).Serum sIL 6R and sgp130 le vels in patients with HC had positive correlation with serum totle bilirubin(Bil T),respectively( r =0.474, r = 0.482 , P <0.01),but not with serum alanine aminotransferase(ALT)( r =0.193; r =0.152, P >0.05).Serum sIL 6R and sgp130 may be related to the evolution of disease in patients with HC.