手术及麻醉对消化道肿瘤病人血清细胞因子的影响

EXPRESSION AND CLINICAL SIGNIFICANCE OF GLUTA THIONE S TRANSFERASE π IN GASTRIC CARCINOMA

为探讨手术及麻醉对消化道肿瘤病人围手术期血清细胞因子的影响，将６０例患者随机分成两组，分别选择吸入全麻和静吸复合全麻两种麻醉方式。采用ＥＬＩＳＡ法对患者术前、术毕４ｈ内和术后１周血清ＴＮＦ－α、ΙＬ－６的水平进行检测。结果：患者ＴＮＦ－α水平术前低于正常（Ｐ＜０．０１），术毕术后升高，术后１周仍低于正常（Ｐ＜０．０１）；ＩＬ－６水平术前高于正常（Ｐ＜０．０１），术毕明显高于术前（Ｐ＜０．０１），术后１周降至正常；术毕时，ＩＬ－６水平在两种不同麻醉组有显著差异（Ｐ＜０．０５）；术后１周ＴＮＦ－α与ＩＬ－６呈正相关（Ｐ＜０．０５）。提示检测手术前后细胞因子水平变化可作为肿瘤病人细胞免疫功能监测和衡量应激反应的指标。

To study the expression of glutathione S transferase π (GST π)in gastric cancer and its clinical significance. The expression of GST π in tumors and the surrounding noncance rous stomach mucosa of 75 patients was determined.And the expression of C erbB 2 protein and nm23 protein in gastric tumors was measured by immunohistochemical S P staining. Results showed that GST π was phenotyically expressed in various histological types of gastric carcinoma, the expression of GST π in various types of gastric carcinoma have no significant diffe rence ( P >0.05). The expression of GST π in tumors was significantly higher than in the surrounding noncance rous stomach mucosa( P <0.05). No significant correlation between GST π expression and expression of C erbB 2 protein or the levels of CEA content( P > 0.05). High expression of GST π was demonstrated in all stomach carcinomas. Increment of GST π expression in gastric cancers was correlated with physiological adaption to the malignant change of gastric mucosal cells.