烟曲霉鼻变态反应性病人细胞因子活性水平观察

EFFECT OF SURGICAL OPERATION AND ANAESTHESIA ON SERUM CYTOKINES IN PATIENTS WITH DIGESTIVE TRACT TUMOR

对８６例烟曲霉变态反应性鼻炎病人血清Ｔ细胞亚群、ＩＬ－２、ＩＬ－６和Ｂ细胞生长因子（ＢＣＧＦｓ）活性水平进行了检测，结果显示烟曲霉鼻变态反应病人血清ＩＬ－２、ＩＬ－６、ＢＣＧＦｓ活性水平升高，与对照组比较差异显著；血清Ｔ细胞亚群ＣＤ４／ＣＤ８比值大大高于对照组，存在显著差异。提示：Ｔ细胞及其分泌的细胞因子和Ｂ细胞分化对ＩｇＥ的生成具有调节作用。

To study if surgical poperation and anaesthesia influences cytokine release in different operation periods of digestive tract tumor,60 patients with digestive tract tumor were randomly allocated to receive either inhalation anaesthesia(group 1),or intravenous inhalation anaesthesia(group 2).Blood samples were obtained at the time of preoperation,4h and one week after surgery.The serum TNF α and IL 6 levels were detected by ELISA.The results showed that the serum TNF α levels before or after operation were obviously lower than that of the normal groups( P <0.01),but those of postoperation were higher than that of preoperation( P <0.01).Serum IL 6 levels of preoperation were higher than that of normal (P <0.01),but were significantly lower than that of 4h after operation( P <0.01).After operation it droped to normal level in one week.At the end of operation,there was a marked difference in serum IL 6 level between two different anaesthetic ways( P <0.05).After one week,there was an obvious corelation between the levels of TNF α and IL 6 (P <0.05).It′s valuable to detect serum TNF α and IL 6 levels perioperatively for determining the immune function and stress reaction of digestive tract tumor.Anaesthesia with fentanyl diminished release of cytokines in response to abdominal surgery.