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炎症与冠状动脉慢血流现象 被引量：5

Inflammation and slow coronary flow phenomenon
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摘要 目的探讨炎症在冠状动脉慢血流（CSF）现象形成中的病理生理作用。方法经冠状动脉造影（CAG）诊断为CSF患者38例，CAG显示无管腔狭窄且无慢血流者25例为对照组，使用校正的TIMI血流分级（CTFC）方法评价冠状动脉血流速度。两组均采用ELIA法测定高敏C反应蛋白（hs—CRP）及白细胞介素6（IL-6）浓度，比较两组间hs—CRP及IL-6的差异，分析冠状动脉血流速度与hs—CRP及IL-6的相关性。Logistic多因素分析评价CSF发生的影响因素。结果CSF组hs—CRP和IL-6浓度明显高于对照组。冠状动脉平均血流速度与hs—CRP及IL-6浓度呈正相关。Logistic多因素分析显示hs—CRP和IL-6与CSF的发生相关（P=0．004，0．001）。结论炎症参与CSF的形成。 Objective To explore the pathophysiological effects of inflammation on coronary slow flow phenomenon（CSF）. Methods 38 patients with CSF and 25 control cases with normal coronary flow （NCF） were enrolled in the study. Coronary flow speed of the cases was determined by Thrombolysis in Myocardial Infarction （TIMI） frame count method, hs-CRP and IL-6 were measured with ELISA. Compare the difference of hs-CRP and IL-6 between two groups and evaluate the relationship between coronary flow speed and hs-CRP,IL-6. Results The levels of hs-CRP and IL-6 were much higher in CSF group compared with NCF group. Coronary flow speed was positively associated with hs-CRP and IL-6. Multivariate analysis showed that hs-CRP and IL-6 were independent risks of CSF. Conclusion Inflammation may take part in the formation and progress of CSF.
作者 段红艳 王丽霞 王光公 李永强 卢建敏 王留义 黄彦生
机构地区 河南省人民医院心内科
出处 《中国心血管病研究》 CAS 2010年第1期32-35,共4页 Chinese Journal of Cardiovascular Research
关键词 冠状动脉慢血流 TIMI血流分级 高敏C反应蛋白 白细胞介素6 肿瘤坏死因子-Α Slow coronary flow Thrombolysis in Myocardial Infarction （TIMI） frame count hs-CRP IL-6 TNF-α
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献24

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二级参考文献32

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共引文献38

同被引文献36

  • 1杨丽霞,杨玉霞,齐峰.老年冠心病患者胰岛素抵抗与冠状动脉病变的相关性分析[J].中华老年心脑血管病杂志,2006,8(3):157-157. 被引量：1
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引证文献5

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中国心血管病研究
2010年 第1期

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