乳腺癌血管内皮生长因子的表达及意义

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND ITS CORRELATIONS WITH CLINICOPATHOLOGICAL VARIABLES IN INVASIVE BREAST CANCER

目的探讨血管内皮生长因子（VEGF）在乳腺癌中的表达及其与血管生成，肿瘤转移等参数之间的关系。方法对101例浸润性乳腺癌组织的VEGF表达进行了免疫组化检测。结果正常乳腺组织及良性病变组织均无VEGF表达。乳腺癌VEGF表达与组织分化（P＜0．05），淋巴结转移（P＜0．005），远处转移（P＜0．005）及早期死亡（P＜0．005）密切相关，与乳腺癌组织微血管密度（MVD）亦呈显著相关性（P＜0．05）；与患者年龄，肿瘤大小无关（P＞0．05）。结论VEGF是促进乳腺癌血管生成的主要因素。VEGF阳性的乳腺癌组织分化差，易发生转移，预后不良。

PURPOSE To explore the expression of VEGF in invasive breast cancer and its correlations with angiogenesis. metastasis and other clinicopathological variables. METHODS VEGF was stained immunohistochemically in101 invasive breast cancer. RESULTS No immunostaining of VEGF was observed in normal breast tissues and benign lesions. Good correlations of VEGF expression were noted with histological grades (P<0' 05). lymph nodestatus (P<0. 005), distant metastasis (PRO. 005). early death (within two years) (PRO. 005). and with MVD (P<0. 05), but not with age, tumor size (P>0. 05) in invasive breast cancer. CONCLUSION VEGF is an importantangiogenic factor. Breast cancer patients with VEGF-positive staining may be at high risk for development ofmetastasis and may have un favorable prognosis.