类风湿关节炎患者血清单核细胞趋化蛋白-1水平及与间质性肺疾病的关系

Relationship between the level of MCP-1 expression in sera of RA patients and ILD

目的:研究单核细胞趋化蛋白-1(MCP-1)在类风湿关节炎(RA)发病中的作用,探讨其与RA继发间质性肺疾病(ILD)的关系及其可能的临床价值。方法:选择RA患者60例,按是否存在ILD,分为单纯RA组30例和RA继发ILD组30例,正常对照组20例,应用ELISA测定各组血清MCP-1水平,比较各组MCP-1水平的差异,同时比较各组中实验室指标IgG、IgA、IgM、α2-球蛋白、γ-球蛋白、RF、ESR、CRP及关节肿痛数的差异,并分析以上指标与血清MCP-1表达的相关性。结果:RA患者MCP-1的表达明显高于健康对照组,RA继发ILD组显著高于单纯RA组。RA患者血清MCP-1与IgG、IgM、γ-球蛋白均呈正相关。结论:MCP-1是RA发病中重要的细胞因子,在RA继发ILD过程中可能起着一定的促进作用。

AIM：To investigate the function and clinical significance of monocyte chemoattractant protein-1 MCP-1 in the pathogenesis of rheumatoid arthritis（RA）and the relation ship between the expression of MCP-1 in serum and interstitial lung disease（ILD）secondary from RA.METHODS：60 patients with RA were divided into two groups：30 cases with simple RA group and 30 cases with ILD secondary from RA（RA＋ILD group）.The control group incuided 20 healthy cases.Enzyme linked immunosorbent assay（ELISA）was used to determine the serum expression of MCP-1 in patients healthy controls.The differences of MCP-1 level and other laboratory indexes（IgG,IgA,IgM,α2-G,γ-G,RF,ESR,CRP,and the number of arthrocele）in different groups were compared with software spss13.0.RESULTS：The expression of MCP-1 in simple RA patients was significantly higher than that in the control group（P〈0.05）and significantly lower than that in the RA＋ILD group（P〈0.01）.The level of MCP-1 in serum of RA patieuts was positively correlated with IgG,IgM,and γ-G.CONCLUSION：MCP-1 plays an important role in the pathogenesis of RA and may contribute to the promotion of lung fibrosis in ILD secondary from RA.