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巨噬细胞衍生趋化因子在MRL/lpr小鼠肾组织中的异常表达

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摘要 目的:研究巨噬细胞衍生趋化因子(MDC)在红斑狼疮小鼠狼疮肾炎中的作用。方法:比较MRL/lpr狼疮小鼠和BALB/c小鼠24h尿蛋白,并用逆转录-聚合酶链反应技术(RT-PCR)和免疫组织化学方法检测两组小鼠肾组织MDCmRNA及蛋白表达情况。结果:MRL/lpr小鼠24h尿蛋白高于BALB/c小鼠(P<0.05);MRL/lpr小鼠肾组织MDCmRNA表达较BALB/c小鼠明显升高(P<0.05);MRL/lpr小鼠肾小球、肾小管及间质均有明显MDC蛋白表达,而BALB/c小鼠肾脏未见MDC表达。结论:MDC在红斑狼疮小鼠肾脏组织中的表达增高,说明MDC可能参与介导了小鼠狼疮性肾炎的病变过程。
作者 刘海娜 吴春玲 郭韵 肖卫国
机构地区 中国医科大学附属第一医院风湿免疫科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2010年第1期61-63,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 辽宁省自然科学基金资助项目(20042092)
关键词 巨噬细胞衍生趋化因子 红斑狼疮 系统性 狼疮性肾炎
分类号 R593.242 [医药卫生—内科学]
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参考文献10

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细胞与分子免疫学杂志
2010年 第1期

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