针刺对阿尔茨海默病患者异构前列腺素的影响

Influence of acupuncture on isoprostane in patients with Alzheimer's disease

目的:探讨针刺治疗阿尔茨海默病(AD)的疗效及作用机制。方法:将20例AD患者采用补肾活血针刺法治疗12周,穴取百会、肾俞、血海、膈俞。采用阿尔茨海默病认知评价量表(ADAS-cog)评估临床疗效,采用酶联免疫吸附法分别测定治疗前后患者脑脊液、血浆、尿液中异构前列腺素(8-IPF2α)含量变化。结果:治疗后有效率为90.0%;ADAS-cog得分由治疗前35.70±4.70降低为治疗后31.45±4.08,前后差异有统计学意义(P<0.001)。治疗后患者脑脊液、血浆、尿液8-IPF2α水平均明显降低(均P<0.001)。结论:针刺可改善AD患者的认知功能,其作用机制可能与降低患者脑内脂质过氧化状态相关。

Objective To explore the clinical therapeutic effect of acupuncture on Alzheimer＇s disease （AD） and its mechanism. Methods Twenty patients with Alzheimer＇s disease were treated by acupuncture with reinforcing kidney and activating blood method for 12 weeks and Baihui （GV 20）, Shenshu （BL 23）, Xuehai （SP 10） and Geshu （BL 17） were selected. The clinical therapeutic effect were assessed by comparing the scores of Alzheimer＇s Disease Assessment Scale-Cognitive Section （ADAS-Cog） and 8-IPF2α concentration in cerebrospinal fluid, blood and Urine before and after treatment were detected by using enzyme linked immunosorbent assay. Results After treatment, the effective rate was 90.0%. The score of ADAS-Cog was 35.70＋4.70 before treatment and 31.45±4, 08 after treatment, with a significant difference （P〈0. 001）. The concentration of 8-IPF2α in cerebrospinal fluid, blood and urine were all significantly decreased after treatment （all P〈0. 001）. Conclusion Acupuncture can im- prove the cognitive ability of AD patients and its possible mechanism may be relative to the decrease in lipid peroxi- dation in AD patients＇ brain.