庚型肝炎临床及流行病学分析

CLINICAL AND EPIDEMIOLOGICAL ANALYSIS OF HEPATITIS G

对３３例经聚合酶链反应（ＰＴ－ＰＣＲ）法检测ＨＧＶ－ＲＮＡ阳性的庚型肝炎患者进行临床和流行病学分析。结果发现经血传播１０例（３０．３％），散发性病例２３例（６９．７％）。单纯ＨＧＶ感染６例（１８．２％），ＨＧＶ与ＨＡＶ、ＨＢＶ、ＨＣＶ二重、三重感染者２７例（８１．８％）。临床诊断急性肝炎１６例，慢性肝炎９例，重症肝炎１例，肝硬化５例，肝癌２例。单纯ＨＧＶ感染症状较轻，有轻重黄疸、ＡＬＴ轻度增高，可导致慢性肝炎，肝硬化。结果提示输血是ＨＧＶ感染的传播途径之一，还有其他传播途径，有待进一步研究。ＨＧＶ与ＨＢＶ重叠感染时可能引起重症肝炎、肝癌。

A clinical and epidemiological analysis was carried out in 33 cases of hepatitis G,whose HGV RNA was positive examined by PT PCR.The results indicated ten cases were infected by blood transfusion (30.3%),the rest were sporadic cases(69.7%).6 patients were infected with single HGV(18.2%),27 patients were of duet or trio with HGV and HAV,HBV or HCV(81.8%),clinical diagnosis results were as follows:16 patients were victims of acute hepatitis;9,chronic hepatitis;1,severe hepatitis;5,cirrhosis;2,were cancer of liver.The symptom of those patients infected by single HGV was slight,but with mild juandice and ALT increase in serum,which indicated chronic hepatitis and cirrhosis.The results of this paper suggested that blood transfusion is one of the spreading routes for HGV infection, but there might exist other routes.The patients of duet infection by HGV and HBV can lead to severe hepatitis and cancer of liver,to which more attention should be paid.