摘要
3-噻吩甲醛与硝基甲烷经缩合、KBH_4还原、与甲醛缩合、环合得到4,5,6,7-四氢噻吩并[2,3-c]吡啶,然后与α-溴代邻氯苯乙酸甲酯反应,得到硫酸氢氯吡格雷的位置异构体α-(2-氯苯基)-4,5-二氢噻吩并[2,3-c]吡啶基-6(7H)-乙酸甲酯盐酸盐,可作为前者质量研究的参照物。
Methyl α- (2-chlorophenyl) -4,5-dihydrothieno [2,3-c]pyridin-6 (7H) -acetate hydrochloride, the positional isomer of clopidogrel hydrogen sulfate, was synthesized by condensation of 3-thiophenecarboxaldehyde with nitromethane, reduction with KBH4, condensation with HCHO and cyclization to give 4,5,6,7-tetrahydrothieno [2,3- c] pyridine, which was reacted with methyl 2-bromo-2- (2-chlorophenyl) acetate.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2010年第1期6-8,共3页
Chinese Journal of Pharmaceuticals
关键词
硫酸氢氯吡格雷
位置异构体
合成
clopidogrel hydrogen sulfate
positional isomer
synthesis