摘要
莪术油葡萄糖注射液收载于中国药典2005年版二部,是由莪术油、葡萄糖和适当助溶剂制成的含药输液剂,临床用于抗病毒的治疗。其中,莪术油为温莪术经水蒸汽蒸馏提取的挥发油,含有莪术二酮(curdione,1)、栊牛儿酮(germacrone,2)、莪术醇与β-榄香烯等多种有效成分。该制剂质量标准中规定以莪术醇为对照品,与香草醛硫酸溶液显色后以比色法测定。
An HPLC method was established for the determination of curdione and germacrone in zedoary turmeric oil and glucose injection. A C18 column was used with the mobile phase of acetonitrile and 0.1% phosphoric acid for gradient elution at the detection wavelength of 210 nm. The calibration curves of curdione and gerrnacrone were linear in the concentration ranges of 10 - 200 μg/ml and 5 - 100 μg/ml. The recoveries were 99.6% (RSD 1.2%) and 99.8% (RSD 2.0%).
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2010年第1期43-45,共3页
Chinese Journal of Pharmaceuticals
基金
黑龙江省教育厅资助项目(11521277)