氧青霉烷的研究

2-Amino-5- oxo- 2- tetrahydrofuran carboxylic acids, novel γ lactone antibacterial agents

合成了氧青霉烷环，用Ｐｄ（ＡｃＯ）２和Ｃｓ２ＣＯ３代替了Ｚｎ（ＡｃＯ）２和ＤＢＵ后，总收率比文献报道提高了一倍。初步证明氧青霉烷可抑制某些酵母样和丝状真菌生长。

Five 2 amino 5 oxo 2 tetrahydrofuran carboxylic acids were designed and synthesized as new antibacterial agents. Their chemical structures were identified by MS, IR, 1 H NMR. All target compounds exhibited potent antibacterial activity against most of the 20 strains of Gram negative and Gram positive bacteria tested, and compound 3e showed equal activity to ceftriaxone against most of them.