小剂量奥氮平对功能性消化不良伴抑郁及焦虑患者的治疗研究

Effect of olanzapine on patients with functional dyspepsia, depression and anxiety

目的观察奥氮平对功能性消化不良（FD）伴抑郁、焦虑患者的临床疗效。方法选择FD伴抑郁及焦虑患者64例，随机数字表法分成对照组和治疗组，每组32例，对照组给予多潘立酮（10mg，3次／d），治疗组在多潘立酮的基础上加用奥氮平（2．5mg，每晚1次），疗程2周，观察治疗前后嗳气、恶心、腹胀、腹痛、腹泻、便秘等症状变化。结果治疗组对嗳气有效率为84．6％（22／26）、恶心有效率为86．7％（13／15）、腹胀有效率为81．2％（26／32）、腹痛有效率为90．4％（19／21）、纳差有效率为85．7％（18／21）、失眠有效率为84．6％（11／13），总改善率为85．2％（109／128），明显高于对照组49．5％（59／111）。2组均未出现明显药物不良反应。结论小剂量奥氮平能明显改善功能性消化不良伴抑郁、焦虑患者的消化不良症状。

Objective To validate the safety and efficacy of olanzapin in the treatment of patients with functional dyspepsia （FD）, depression and anxiety. Methods Sixty-four patients with FD, depression and anxiety were recruited and randomly divided into two groups. The control group was given domperidone （ 10 mg po, rid） and the observed group was given domperidone （10 mg po, tid） plus olanzapine （2.5 mg, po, qn）. The treatment circumstance was recorded one day before the treatment and weekly in a two weeks＇ therapy. Results After 2 weeks＇ observation, alleviation rates of eruetion, naupathia, abdominal pain, poor appetite and insomnia were 84.6%, 86. 7%, 90.4%, 85.7% and 84.6% , respectively. The observed group had overall efficiency of 82% and the control group had 45%. No side effect was observed. Conclusion Low dose olanzapine can improve the dyspepsia symptoms of the patients with FD, depression and anxiety.