1023例泌尿生殖道支原体培养和药敏结果分析

SUSCEPTIBILITY TEST OF MYCOPLASMA IN GENITOURINARY TRACTS OF 1023 CASES

目的了解解脲支原体(Uu),人型支原体(Mh)的感染状况及其常用治疗药物的体外敏感性,指导临床合理用药。方法应用Mycoplasma IST试剂盒进行支原体检测及药敏分析。结果1023例疑似非淋菌性尿道炎(NGU)患者中357例支原体培养阳性,阳性率为34.9%;其中Uu阳性257例(阳性率为25.1%),Uu+Mh阳性91例(阳性率为8.9%),Mh阳性9例(阳性率为0.9%)。对环丙沙星的耐药率最高,占68.0%;其次为氧氟沙星和红霉素,分别为58.0%和50.9%;对司帕沙星、左氧氟沙星、四环素、美满霉素、罗红霉素、多西环素、克拉霉素、阿奇霉素、交沙霉素的耐药率分别为38.1%,31.5%,10.1%,5.1%,4.7%,4.3%,3.1%,2.7%,0.8%。结论加强支原体的药敏检测,根据药敏结果合理用药,对防止支原体耐药株产生具有重要意义。

Objective To acquire the information about the present resistance characteristics in Ureaplasma Urealyticum （Uu） and Mycoplasma hominis （Mh）, and to instruct reasonable application of antibiotics clinically. Methods Mycoplasma IST kits were used to measure the mycoplasma and to analyze the drug susceptibility. Results Among 357 cases with non-gonoccocal urethritis（ NGU ）, mycoplasma positive rate was 34.9% ,Uu positive were 257 cases （ positive rate 25.1% ） ,Uu and Mh positive were 91 cases （positive rate 8.9%） ,Mh positive was 9 cases （ positive rate 0.9% ）. The result of susceptibility test showed that the highest resistant rate was caused by Ciprofloxacin （68.0%）,next was done by Ofloxacin （58.0%） and then by Erythromycin （50. 9% ）, The resistant rates to Sparfloxacin, Levofloxacin, Tetracycline, Minocycline, Roxithromycin, Doxycycline, Clarithromycin, Azithromycin, Joxamycin was 38. 1%, 31.5%, 10.1%, 5.1% , 4.7% , 4.3%, 3.1%, 2.7%, 0.8% , respectively. Conclusion It is important to strengthen the detection of drug resistance of mycoplasma, guide the drug use and prevent from producing antibiotic resistant mycoplasma.