女性不孕不育血清相关自身抗体检测的分析

Analysis of female infertility related serum autoantibodies detection

目的:探讨自身抗体检测对女性不孕不育诊断的意义。方法:采用化学发光法测定149例原发性不孕、466例继发性不孕、320例习惯性流产及45例正常生育妇女血清抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)、抗心磷脂抗体(ACA)水平。结果:原发性不孕组中,AsAb阳性率为26.17%,EmAb阳性率为17.45%,ACA阳性率为12.75%;继发性不孕组中,AsAb阳性率为28.97%,EmAb阳性率为20.17%,ACA阳性率为19.10%;习惯性流产组中,AsAb阳性率为19.06%,EmAb阳性率为9.06%,ACA阳性率为28.12%;对照组中,AsAb和ACA阳性率为2.22%,EmAb为0%。不孕不育各组的阳性检出率均高于对照组,差异有统计学意义(χ2=33.02,P<0.05)。结论:血清相关自身抗体检测对女性免疫性不孕不育的诊断有重要意义。

Objective： To investigate the diagnostic significance of female infertility related autoantibody detection. Methods： Chemiluminescent method was applied to detect levels of antisperm anti- body（AsAb）, endometrial antibody （EmAb）, anticardiolipin antibody （ACA） in 149 cases of primary in- fertility, 466 cases of secondary infertility, 320 cases of habitual abortion and 45 cases of normal reproduc- tive women. Results： The positive rate of AsAb,EmAb,and ACA was 26.17%, 17.45%, and 12.75% in the primary infertility group, 28.97%, 20.17%, 19.10% in the secondary infertility group, and 19.06%, 9.06%, 28.12% in the habitual abortion group, while in the normal control group, the positive rate of AsAb, ACA and EmAb were 2.22 %, 2.22% and 0. Postive rate of AsAb, ACA and EmAb of infertility group were all significant higher than that of the control （x2 =33.02,P〈0.05）. Conclusion： The detection of serum autoantibodies associated with the female immune infertility is informative for diagnosis.