前列腺特异性抗原密度诊断前列腺偶发癌的临床价值

Diagnostic value of prostate specific antigen density in incidental adenocarcinoma of prostate

为探讨前列腺偶发癌早期诊断的有效指标，对11例前列腺偶发癌和20例前列腺增生症（BPH）患者前列腺特异性抗原密度（DPSA）进行了检测。结果前列腺偶发癌DPSA平均值为0．15±0．13ng／（ml·cm3），BPH为0．07±0．06ng／（ml·cm3），两者有非常显著性差异（P＜0．01）。11例DPSA＞0.1ng／（ml·cm3）者，9例为前列腺偶发癌；20例DPSA＜0．1ng／（ml·cm3）者，18例为BPH。而有9例前列腺偶发癌前列腺特异性抗原（PSA）＜10．0ng／ml，有12例BPH者PSA＞2.8ng/ml。认为当患者血清PSA轻、中度增高或正常时，DPSA可作为前列腺偶发癌早期诊断的有效指标。

Prostate specific antigen density DPSA was studied in 11 cases of incidental adenocarcinoma of prostate and 20 cases of benign prostatic hyperplasia (BPH). The mean DPSA values in patients with incidental adenocarcinoma of prostate and BPH were 0. 15±0. 13 ng/(ml·cm3) and 0.07±0. 06 ng/(ml·cm3) respectively (P＜0. 01). 9 out of 11 patients with DPSA value greater than 0.1 ng/(ml·cm3) had incidental adenocarcinonta of prostate. In contrast, 18 out of 20 patients with DPSA value less than 0. 1 ng/(ml·cm3) had BPH. 9 cases of incidental adenocarcinoma of prostate were found to have a PSA value less than 10.0ng/ml and 12 cases of BPH greater than 2.8 ng/ml. The results showed that DPSA wiht be an effective indicator in screening early incidental adenocarcinoma of prostate when the serum PSA value was normal or moderately high.