泌尿生殖系恶性淋巴瘤PCNA表达与预后的关系

A preliminary study on the expression of PCNA in malignant lymphoma of genitourinary tract and its relationship with histopathologic classification and prognosis

为探讨评估泌尿生殖系恶性淋巴瘤预后的有效指标，应用免疫组化法对6例泌尿生殖系恶性淋巴瘤组织中增殖细胞核抗原（PCNA）及免疫表型进行检测，结果PCNA增殖指数与免疫表型和形态学类型有关，免疫表型或肿瘤生物学行为属T细胞淋巴瘤的PCNA指数高于B细胞和非T非B细胞淋巴瘤，前者术后仅生存3～5个月，后者术后生存2年2个月～5年。认为PCNA对判定泌尿生殖系恶性淋巴瘤的预后有一定意义，可能成为评估淋巴瘤患者预后的重要指标之一。

Proliferating cell nuclear antigen (PCNA) and immunotyping were assayed in 6 cases of malignant lymphoma of genitourinary tract using the immunohistochemical technique. The results reveled that the patient with high PCNA index of immunotyping T-cell type died significantly earlier than immunotyping B-cell type or non T-cell and non B-cell type cases. Our findings suggest that PCNA might be applicable as a tumor marker for the evaluation of prognosis of malignant lymphoma of genitourinary tract.