低剂量粒-巨噬细胞集落刺激因子在肺癌化疗中的应用

Low dose GM CSF administration in chemotherapy of lung cancer

３１例肺癌患者大剂量化疗４０例次，采用配对法分成加用低剂量粒－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）的治疗组及不加用的对照组（二组均为２０例次）。结果表明，低剂量ＧＭ－ＣＳＦ明显缩短化疗所致白细胞低下的时间：治疗组为１４．５±９．４９天，对照组为１９．４±８．８５天（Ｐ＝０．０２），同时提高白细胞下降最低值：治疗组为３．３５×１０９／Ｌ±１．３７×１０９／Ｌ，对照组为２．９×１０９／Ｌ±１．１８×１０９／Ｌ。低剂量ＧＭ－ＣＳＦ的主要不良反应为发热（８０％）及肌痛、骨痛（１０％）。

Forty cases of lung cancer after chemotherapy were paired and divided into two groups.Group 1 was treated by chemotherapy combined with low dose GM CSF (75 μg qd×8) and Group 2 by chemotherapy alone.The result showed that GM CSF had significant effect in reducing the duration of leukocytopenia:Group 1 was 14.5±9.49 days,Group 2 was 19.4±8.85 days ( P =0.02)。Besides,the nadir values for leudocytopnia was increased:Group 1 was 3.35±1.37×10 9/L,Group 2 was 2.90±1.18×10 9/L.The main side effects of low dose GM CSF were fever (80%),myosalgia and bone pain (10%).It suggests that low dose GM CSF can support the dose intensive therapy in lung cancer.